An FRT site, IRES, lacZ, loxP site, neomycin selection cassette, FRT site, and loxP site were inserted upstream of exon 10 and a third loxP site was inserted downstream of exon 11. Flp-mediated recombination removed the lacZ and neomycin cassette leaving exons 10-11 floxed. (J:293763)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count