CRISPR/Cas9 genome editing is used to insert a codon improved cre recombinase (iCre), a woodchuck hepatitis virus post-transcriptional regulatory element (WPRE; to enhance the mRNA transcript stability), and a polyadenylation sequence in place of the start codon of the tectorin alpha (Tecta) gene. (J:286224)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count