A loxP sequence and an frt-flanked pgk-neomycin selection cassette was inserted into a site 107 bp upstream of exon 11. A second loxP site was introduced into a site 113 bp downstream of exon 11. Exon 11 was deleted via Cre-mediated recombination in the germline. (J:272765)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count