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Exon 2 was targeted with three shRNA guide sequences (5'-ACACTATCTGGAGTCACTTA-3', 5'-CTACCTAGTAGCCAAGACTG-3', 5'-AGTCATCTGGAAGATGGTGC-3') using CRISPR/Cas9 technology. One founder mouse presented with an insertion of a G nucleotide in exon 2 (c.301_302insG), causing a frameshift and premature termination. (J:291290)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
