The cDNA for exons 2-9 and the coding part of exon 10, comprising the entire coding region plus part of the 5' UTR, was placed downstream of a tetracycline response element (TRE) and minimal CMV promoter, followed by beta-globin intron and poly signal sequences. Expression of this transgene can be controlled by tetracycline/doxycycline in conjunction with a tTA or rtTA expressing allele. The transgene construct was injected into blastocysts homozygous for the Phenotypes
Basic Information
C57BL/6N-Btnl1tm1(KOMP)Mbp
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count