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The targeting construct is designed to insert a loxP site downstream of exon 14 and an FRT-flanked neomycin (neo) resistance cassette, followed by a second loxP site downstream of exon 16. A CCA to TCA mutation was introduced in exon 16, encoding activation domain 2, converting a proline to a serine (P1278S) similar to a mutation found in a small cohort of bone metastases from breast cancer patients. Flp-mediated recombination removed the FRT-flanked neomycin cassette. (J:341575)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
