CRISPR/Cas9 technology generated a 47 bp deletion in the 5' regulatory region (chr7:126781201-126781247, GRCm38/mm10) of Tbx6. qRT-PCR and RNA in situ hybridization indicate that Tbx6 RNA expression is elevated. (J:288810)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
C57BL/6J
Endonuclease-mediated
Intragenic deletion
--
1
2
1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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