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Exons 4 to 9 were flanked by loxP sites and an FRT-flanked neomycin selection cassette was inserted downstream of the second loxP site. Flp-mediated recombination removed the selection cassette. Cre-mediated recombination deleted exons 4-9 in the germline. Western blot analysis indicates loss of the two highest molecular weight isoforms (C-1, C-2, N-1, and N-2 bands) and a reduction in other isoforms (bands C-3, C-7, and N-3 on the blot) indicating a complex alteration of isoforms. (J:289884)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
