CRISPR/Cas9 endonuclease-mediated genome editing introduced an indel comprised of a 16 bp (Chr7:29013738 to 29013752) deletion in exon 96 of the gene. Sequencing N1 pups revealed the repair template was not incorporated into this allele, which resulted from non-homologous end-joining repair of the double strand break. (J:275500)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count