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CRIPSPR-targeting replaced the sequence encoding the methyl-CpG binding domain (MBD) of Mecp2 (NCBI NM_010788 c. 280-492 and intron 3; p. 94-164) with the homologous sequence from MBD2 (NCBI NM_010773 c. 457-651, excluding the intron; p. 153-217). The gene was tagged at the C-terminus by EGFP connected with a short linker (TGTAAGGATCCACCGGTCGCCACC). Cre-mediated recombination removed the selection cassette in intron 2. (J:309631)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
