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The targeting vector was used to introduce the human R684H, F681Y, G676R and KM670/671NL (Swedish) mutations into to exon 16. An FRT-flanked PGK-neomycin cassette (in reverse transcriptional orientation), and an F3-flanked PGK-hygromycin cassette (in reverse transcriptional orientation) is placed in intron 16, and the E693G (Artic) and T714I (Austrian) mutations are introduced to exon 17. Flpe-mediated recombination removed the FRT-flanked neomycin and hygromycin cassettes. (J:299724)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
