CRISPR/Cas9 genome editing is used to introduce loxP sites on either side of the exons 3-4. Resultant mice were sequenced to identify mice homozygous for both loxP insertions. (J:289029)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count