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The region containing Mir34b and Mir34c was flanked by loxP sites. The distal LoxP site was inserted into a non-conserved region approx. 400 bp downstream of Mir34c. A positive selection cassette (NeoR) was flanked by FRT recombination sites and co-inserted with the proximal LoxP site into non-conserved regions approx. 800 bp upstream of Mir34b sequence. The conditional allele was obtained after Flp-mediated removal of the selection marker. Cre-mediated recombination removed the microRNA cluster. (J:147112)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
