CRISPR/Cas9 endonuclease-mediated genome editing was used to insert loxP sites in intron 2 and intron 3 (creating a floxed exon 3). Cre-mediated recombination removed exon 3. (J:94077)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count