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Within the VH186.2-DFL16.1-JH2 sequence of the genomic DNA of B1-8hi mice, the Leu33 TTG codon was changed to TGG (Trp) and the B1-8 germline fragment was subcloned into a targeting vector which was electroporated into Bruce4 ES cells to generate homologous recomination. After generation of chimeric mice, the neomycin-resistance gene (neor) was removed by crossing to CAG-Flp transgenic mice. (J:260241)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
