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An ERT2cre-encoding gene fused with a poly(A) signal and a neomycin-kanamycin resistance gene flanked with two FRT sites were inserted into the exon 2 of the S1pr2 gene, which encodes S1P2, on a BAC clone (RPCI23.C-168D6). Correctly targeted clones were injected into pronuclei of C57BL/6 zygotes to generate transgenic funder lines. The founder mice were identified by PCR and were further crossed with CAG-Flp transgenic mice to remove the neomycin-kanamycin resistance gene cassette. Line numbers were not indicated. The pound symbol (#) is used when no line is specified and/or lines are pooled. (J:260241)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
