Exon 3 was flanked by loxP sites (size of loxP-flanked region is 0.8 kb). The positive selection marker (Puromycin resistance - PuroR) was flanked by FRT sites and inserted into intron 3. The conditional allele was generated after Flp-mediated recombination. (J:147112)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count