LoxP sites were inserted into non-conserved intronic regions 553bp upstream and 530bp downstream of exon 2. The 3' LoxP site was preceded by a Frt-flanked neomycin (Neo) cassette. The neomycin selection cassette was removed in the germline via FLP-mediated recombination. (J:287691)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count