To generate mice with multi-megabase duplication or deletion of Slxl1 ampliconic region, loxP sites were sequentially integrated upstream and downstream of the Slx ampliconic region via CRISPR. (J:304511)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count