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The single coding exon was replaced with an IRES-lacZ-neomycin resistance cassette and a bovine growth hormone polyadenylation signal, followed by a PGK-puromycin resistance cassette. RT-qPCR analysis confirmed the absence of mRNA expression in the cerebral cortex and pancreatic islets isolated from homozygous mutant mice. Unexpectedly, Gpr27 deletion reduced expression of Eif4e3, a neighboring gene, likely by deleting transcription start sites on the anti-sense strand of the Gpr27 coding exon. (J:286854)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
