The targeting vector contains (from 5' to 3') a ubiquitously expressed CMV-IE enhancer/chicken beta-actin/rabbit beta-globin hybrid promoter (from pCAGGS), a single FRT site, loxP-flanked stop cassette (containing 3x SV40 polyadenylation [pA] sites), a red fluorescent protein (mCherry) tagged human ATPase, Ca++ transporting, plasma membrane 2 (ATP2B2) splice variant w/b sequence, an SV40pA site followed by a woodchuck hepatitis virus posttranscriptional regulatory element (WPRE), and a neomycin resistance (neo) cassette followed by another SV40pA site. (J:316361)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count