CRISPR/Cas9 endonuclease-mediated genome editing is used to target exon 3 of the gene. Double stranded oligonucleotide donor DNAs were created encoding a deletion of 559 nucleotides (and a 1 nucleotide deletion one nucleotide down from the larger deletion) in exon 3. (J:101977)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count