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The human MAPT sequence from exon 1 to exon 14 (NCBI Reference Sequence: NG_007398 with H2 haplotype) and a loxP/FRT flanked neomycin resistance gene replaced the entire genomic sequence (from exon 1 to exon 14) of murine Mapt via homologous recombination. Cre-mediated recombination removed the neomycin gene. Western blot analysis confirmed the expression of all human tau isoforms. (J:278451)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
