Myo7a^{tm1b(EUCOMM)Wtsi}

Cre-mediated excision of the parental Myo7atm1a(EUCOMM)Wtsi allele resulted in the removal of the promoter-driven neomycin selection cassette and critical exons 10-11 leaving behind the inserted lacZ reporter sequence. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml. Western blot analysis confirmed the absence of protein expression in the eye and inner ear. LacZ expresion was not detected. (J:283233)