This allele was generated at The Jackson Laboratory by electroporating Cas9 protein and 2 guide sequences GCCAATGGGAGAACGCACAG and GTACTTTCGTTGTACCCTGA, which resulted in a 2664 bp deletion beginning at Chromosome 3 position 137,864,450 bp and ending after 137,867,113 bp (GRCm38/mm10). This mutation deletes ENSMUSE00000669244, ENSMUSE00001255094, ENSMUSE00001280001, ENSMUSE00001260075, ENSMUSE00000635681 (exons 1-5) and 1575 bp of flanking intronic sequence including the splice acceptor, donor and start site. This deletion is predicted to generate a null allele. (J:188991)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
C57BL/6NJ
Endonuclease-mediated
Intragenic deletion
Not Specified
1
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Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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