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Histidine codons 292 and 295 were targeted for mutation to arginine codons with an oligonucleotide donor sequence and an sgRNA using CRISPR/Cas9. This resulted in p.His292Arg and p.His295Arg mutations (plus a silent mutation) in this allele. The mutations in the RING domain lead to transactivation of Wnt signalling. (J:276360)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
