Log In|Sign Up
EN
Using an sgRNA (ACAAAGTTGTCTTCTTCTAC), a donor oligonucleotide (AACTACTTAAATTACTGTTTTAAGTATACTAAATGTTTTTTATATTTTTCAGAAATTTTGGCGGAAGCATGCAGAAGAAGACAACTTTGTAAAGAATCTACTGCCTCTGAAGAACTAAGTAAGTATATT) and CRISPR/Cas9 technology, codons 647-649 were changed from LeuThrPro to AlaGluAla (p.Leu647_Pro649delinsAlaGluAla). This abolishes the telomeric repeat binding factor 1 (Terf1)-binding domain. (J:286164)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
Show/Hide columns
| Phenotypes |
|---|
References Literature
Title
PMID
Journal
Year
IF
