The bacterial artificial chromosome, RP24-227B3, containing the entire Il22 gene plus upstream (30 kb) and downstream (2 kb) regulatory sequences was modified to insert EGFP cDNA downstream of the Il22 exon 1 followed by an FRT-flanked neomycin cassette. The neomycin cassette was later removed using FLP recombinase leaving one FRT site. (J:286232)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count