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The transgene construct consists of the following elements: the human small nuclear RNA 6 promoter driving expression of an sgRNA targeting exon 2 of the the Notch1 gene; a human keratin 14 promoter driving squamous epithelium-specific expression of the cas9 gene; poly(A) signal sequences. In mice carying this allele, the Notch1 gene is knocked out in tissues where the KRT14 promoter is active. Two F0 founder mice were found. Founder 2 has a 5 bp deletion (AGCCA), causing a reading frameshift and premature translation termination. (J:233171)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
