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An open mutation was generated by inserting an FRT-flanked neomyn cassette between exon 1 and 2, and deleting 24bp (TACACTCAGGAACTCGGGGCCTTT; aa sequence: YTQELGAF) from exon 2. An additional two amino acids (AK to IS; bp change: GCCAAA to ATATCA) deletion created an EcoRV site in exon 2. The modified exon 2 and exon 3 were also floxed to provide the capacity for generating a null allele. Flp-mediatd recombination removed the selection cassette. (J:281449)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
