Exons 3 and 4 were flanked by LoxP sites. Positive selection markers were flanked by FRT (NeoR) and F3 (PuroR) sites and inserted into intron 2 and intron 4, respectively. Flp-mediated recombination resulted in the removal of selection markers. (J:253621)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count