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This CRISPR/Cas9 mediated deletion of a single nucleotide T at position 2579, in exon 7, results in a a phenylalanine to serine mutation at amino acid 860 which causes a frameshift mutation that introduces a stop codon. Semi-quantatative PCR and Western blot analysis indicate this is a null allele. (J:284762)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
