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Using CRISPR/Cas9 technology, a T>G mutation was created in the FVB strain, converting a deleterious mutation (SNP rs13477613) in FVB (and A/J) to the reference, non-pathogenic, sequence of the B6 strain. This results in a serine codon in FVB changing to the B6 arginine codon. (J:282171)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
