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The zinc finger nuclease induced mutation targets residue 57 of the gene, resulting in a serine to aspartic acid mutation (S57D). The mutation at position 57 (S57D) in the MHC class II A chain disrupts the expression of the diabetes susceptible MHC class II I-Ag7 molecule uniquely expressed in NOD mice. (J:284226)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
