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This randomly integrated transgene encodes a membrane-bound (using the transmembrane domain of the mouse H2-Db) version of chicken ovalbumin in which additional T cell antigenic peptide epitopes are embedded. These additional epitopes include 2W1S (EAWGALANWAVDSA), and lymphocytic choriomeningitis virus (LCMV) gp33 (KAVYNFATM) and gp66 (DIYKGVYQFKSV), which function as the Universal Self Antigen (USA). Expression is driven by the CAG (beta actin) promoter, and is made conditional by the upstream insertion of a transcriptional stop signal flanked by loxP sites. (J:284012)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
