A cDNA encoding Dre recombinase was iserted into the site encoding the translational start codon of the Krt19 gene, using the CRISPR/Cas9 technology. The woodchuck hepatitis virus post-transcriptional regulatory element (WPRE) were placed after the Dre cDNA sequence to stabilize the Dre-encoding mRNA. (J:278073)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count