The targeting vector is designed to insert a loxP site upstream of exon 2, and a FRT-PGK-neo-pA-SD-IS-FRT cassette followed by a second loxP site downstream of exon 2. The SD is a splice donor sequence and the IS is a 54bp instability signal. (J:283234)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count