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The transgene contains 4 repeats of a synthetic HIF-DNA binding sequence (4xHRE) and TK minimal promoter of unknown origin followed by 770-bps -globin intron drives expression of cre recombinase gene fused with the oxygen-dependent degradation (ODD) domain. This transgene is responsive to hypoxia. Six founder lines were identified. The pound symbol (#) is used when no line is specified and/or lines are pooled. (J:281517)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
