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A targeting construct was generated by a combination of gene synthesis and recombineering. The Cre coding sequence and a frt-flanked neomycin (Neo) cassette were inserted into exon 1 of the Robo3 locus to replace the endogenous translation initiation codon and subsequent 31 nucleotides. The Neo cassette was subsequently deleted by crossing the chimeras to FLPe mice. (J:282827)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
