The targeting vector was designed to insert loxP sites flanking exon 1, which contains the start codon of the gene. The construct also included an FRT-flanked neomycin resistance (neo) cassette. FLP-mediated recombination removed the neo cassette. (J:98514)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count