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EN
The L1L2_Bact_P cassette was inserted at a position on Chromosome 14 downstream of exon 4. The cassette is composed of a FRT site followed by En2SA (mouse engrailed 2 gene splice acceptor), internal ribosome entry site (IRES) fused to a beta-galactosidase (lacZ) gene, and a polyadenylation site (SV40 polyA). This was followed by a loxP-flanked cassette containing a neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. A third loxP site is inserted downstream of exon 8. Flp-mediated recombination removed the FRT-flanked neo cassette leaving exons 5 through 8 floxed. (J:235867)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
