The targeting vector was designed to insert a loxP site upstream of exon 7, and an FRT-flanked neomycin selection (neo) cassette followed by a second loxP site downstream of exon 8. Flp-mediated recombination removed the FRT-flanked neo cassette. (J:187348)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count