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The targeting vector contains a loxP site placed in intron 5 and an FRT::neomycin-delta thymidine kinase (Neo-DTK)::FRT::loxP cassette placed in intron 7. Flp-mediated recombination removed the FRT-flanked neomycin cassette. Cre-mediated recombination removed exons 6 and 7. The deletion creates a premature translation termination codon in exon 8 and deletes 80% of the coding region including the entire zinc finger DNA binding domain. (J:282446)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
