This allele was generated at The Jackson Laboratory by electroporating Cas9 protein and 2 guide sequences ATTCACAACCTTGATCAGGA and CCACTGTCCCATTTCTTACG, which resulted in a 489 bp deletion beginning at Chromosome 11 position 119,234,578 bp and ending after 119,235,066 bp (GRCm38/mm10). This mutation deletes ENSMUSE00000389510 (exon 4) and 344 bp of flanking intronic sequence including the splice acceptor and donor and is predicted to cause a change of amino acid sequence after residue 305 and early truncation 15 amino acids later. (J:188991)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count