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A 130-200 kbp bacterial artificial chromosome (BAC) RPC1-22 clone 553 H3 containing the entire ~80 kbp mouse Trpm8 gene was modified to insert a simian diphtheria toxin receptor / enhanced green fluorescent protein fusion gene sequence (DTR/EGFP) followed by an SV40 polyA sequence into exon 2 of Trpm8 locus on the BAC (disrupting the Trpm8 coding region). No other loci on the BAC were altered. The BAC may also include the Ugt1a2, Dnajb3, Ugt1a1, Mroh2a, Hjurp and Spp2 loci. (J:194264)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
