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Using site-directed mutagenesis, arginine codons 206 and 210 in exon 4 were changed to lysine codons (p.R206K, p.R210K). A puromycin resistance gene cassette was inserted downstream of the targeted codons in exon 4. The two targeted arginines are normally methylated as part of the regulation of the peptide's activity; lysines cannot be methylated. (J:281491)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
