This allele was generated at The Jackson Laboratory by electroporating Cas9 protein and 2 guide sequences TCTGGGCTCAGTCGACCTAA and GCTCCTTGCAATTTACTGGA, which resulted in a 516 bp deletion beginning at Chromosome 17 position 35,520,715 bp and ending after 35,521,230 bp (GRCm38/mm10). This mutation deletes ENSMUSE00000273049 (exon 4) and 212 bp of flanking intronic sequence including the splice acceptor and donor and is predicted to cause a change of amino acid sequence after residue 76 and early truncation 4 amino acids later. (J:188991)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count