This allele was generated at The Jackson Laboratory by electroporating Cas9 protein and 2 guide sequences GGAACATTGGTAATCAACAA and TTTATGGCTGGAGTTGTGGG, which resulted in a 459 bp deletion beginning at Chromosome 8 position 58,535,773 bp and ending after 58,536,231 bp (GRCm38/mm10). This mutation deletes ENSMUSE00001303502 (exon 3) and 350 bp of flanking intronic sequence including the splice acceptor and donor and is predicted to cause a change of amino acid sequence after residue 46 and early truncation 35 amino acids later. (J:188991)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count