A loxP site was inserted upstream of exon 1 and an FRT flanked pgk-neo cassette and loxP site were inserted downstream of exon 1 via homologous recombination. Flp mediated recombination removed the pgk-neo cassette. (J:279065, J:280829)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count