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Exons 7 and 8, encoding the code region of the JmjC demethylase domain, were flanked by loxP sites. A FRT-flanked neomycin resistance gene was inserted downstream of exon 8 before the second loxP site. Cre-mediated recombination deleted exons 7 and 8 and the selection cassette in the germline. Western blot and immunostaining on brains confirmed absence of protein. (J:258245, J:280387)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
